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Adding GIP (the dual-agonist tirzepatide step) meaningfully amplifies the satiety and adipose-tissue effects beyond what GLP-1-only molecules achieve, despite earlier scepticism that GIP signalling was non-functional in type-2 diabetes
In rare cases, ongoing headache symptoms from GLP-1 could signal an underlying issue that needs medical attention
In particular, adipose tissue, or fat cells, produce hormones known as adipokines, which regulate metabolism and appetite
Jeppesen PB, Pertkiewicz M, Forbes A, Pironi L, Gabe SM, Joly F, et al
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