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Presented for research literature review only Lyttle MH et al
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Findings suggest this interaction may trigger signal cascades involving second messengers such as cAMP, leading to downstream transcriptional activity related to GH synthesis
Treatment with FOXO4-DRI at 25 M in serum-limited senescent fibroblast and keloid organ culture models promoted apoptosis, decreased G0/G1 phase cells, and induced p53-pS15 nuclear exclusion confirmed by Annexin V-FITC/PI apoptosis assays and TUNEL staining of keloid organ cultures at days 3, 7, and 10
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