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Hruz, P
Cost is one of the most common reasons patients ask about oral options
The D-Phe at position 7 (D-Phe-7 in -MSH numbering) is a well-known potency-enhancing substitution originally identified by Hadley and colleagues in linear -MSH analog studies, the D-stereochemistry produces a constrained backbone conformation that fits the melanocortin receptor binding pocket with enhanced affinity
Food intake, particularly ingestion of carbohydrate-rich food, increases GLP-1 secretion, which promotes post-prandial insulin secretion, -cell proliferation, and glucose homeostasis, contributing to reducing glucose levels and aiding weight loss
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