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Biliary excretion of a glutathione conjugates of busulfan and 1, 4-diiodobutane in the rat

Moreover, elevated insulin levels resulting from hyperinsulinemia trigger insulin-like growth factor (IGF) signaling, activating key pathways such as phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) [26]

In clinical contexts, AOD 9604 has also been evaluated in obesity-related trials, where ongoing work continues to assess its potential role

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