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The first studies on heteromers of the D 4 R polymorphic variants, based on BRET and co-immunoprecipitation techniques in transfected mammalian cells, suggested that the D 4.7 R establishes weaker intermolecular and functional interactions with the D 2 R (both isoforms, D 2L R and D 2S R) than the D 4.4 R (52, 56, 57)

Adapted from Ruiz-Colon et al, 2014), Recommended Treatment: No known antidote, or FDA-approved medications to manage xylazine overdose or withdrawal Xylazine is not detected in routine toxicology screens (Rubin, 2022) naloxone treatment does not appear to be of benefit (Ruiz-Colon et al, 2014) Maintain respiratory function & blood pressure & supportive care (Ruiz-Colon et al, 2014

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