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For Ga, Rh, and As, progress will likely come from pairing speciation-aware discovery with high-throughput binding assays, then refining hits through iterative engineering informed by coordination chemistry and local electrostatics
5.2 Mitochondrial dysfunction Mitochondrial dysfunction plays a pivotal role in the pathogenesis of HTN-related OS, acting as both a major source and a vulnerable target of ROS in the cardiovascular system
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