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Macrogol 3350 with electrolytes (the UK equivalent of Miralax) is an osmotic laxative that works by retaining water in the bowel, softening stools and making them easier to pass
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10.1152/ajprenal.00254.2020 21 Cichoz-LachH.MichalakA
The most plausible explanation is the glucagon arm, which is the one thing retatrutide has that the others dont and if thats right, it may be an unavoidable cost of the mechanism rather than something you can engineer away
The NHS advises adults to consume no more than 6 g of salt per day
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