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In almost all animal studies aimed to investigate the effect of CR on oxidative stress in the heart, H 2 O 2 was found to be reduced together with an increase in the antioxidant capacity in response to CR and with an increase in mitochondrial differentiation (mitochondrial protein/gram of tissue and mitochondrial protein/mitochondrial DNA) (Colom et al., 2007)
No subsequent clinical studies of FGF21 analogs in adults have demonstrated a significant effect on bone density or markers of bone resorption and formation in adults (245, 246, 295)
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