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HUBERMAN: But in addition to that, that you really think about using the minimal effective dose and that you use perhaps even the mildest of these different compounds in order to make sure that you don't desensitize any of the receptor pathways

Some translational data have shown that the action of antidepressant molecules such as ketamine may involve direct modulation of the activation state of microglial cells [108]

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Our findings indicate that FOXO4-DRI promotes apoptosis in senescent cells by disrupting the FOXO4-P53 interaction, thereby releasing and phosphorylating P53, which then translocates to the cytoplasm