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Injecting at a 90-degree angle with a quick, confident motion, rotating injection sites at least one inch apart, applying cold therapy before injection, and allowing at least two weeks between injections to the same site all reduce bruising

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A phase I trial (NCT02415621) evaluating adaptive dosing of abiraterone in metastatic castration-resistant prostate cancer demonstrated that intermittent androgen pathway suppression based on PSA dynamics could delay resistance and reduce cumulative toxicity