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In addition, treatment effects estimated using MMRM analyses are typically larger than those seen with MI analyses since the MMRM estimates the treatment effect while participants are adhering to the investigational drug, whereas MI-based estimates (reflecting the intent-to-treat approach) are irrespective of adherence
[149] George Whipple, George Minot and William Murphy were awarded the Nobel Prize in 1934 for their work on the vitamin
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