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References Sikiri P, Seiwerth S, Rucman R, et al
SAM Inhibiting NNMT is reported to raise cellular NAD+ and SAM
The high efficiency of superoxide dismutase seems necessary: even at the subnanomolar concentrations achieved by the high concentrations of SOD within cells, superoxide inactivates the citric acid cycle enzyme aconitase, can poison energy metabolism, and releases potentially toxic iron
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