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Side effects with NAC supplements include gastrointestinal symptoms, which occur in up to 23% of patients.[ref] While generally safe at supplemental doses, a drawback to N-acetyl cysteine is the sulfur smell and taste
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This results in excessive release of dopamine, norepinephrine, and serotonin, which overstimulate postsynaptic receptors and produce the euphoric and stimulant effects associated with METH use (Lee et al., 2009
Secondly, psychosis has been viewed as an adverse event, although rare, in children with ADHD who have been treated with amphetamine 1 2 3 "Stimulant Misuse: Strategies to Manage a Growing Problem" (PDF)
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