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6.1.1 The main components and regulators In muscle or adipose tissue (AT), AKT prompts glucose transporter type 4 (GLUT4) to translocate from the cytoplasm to the cytomembrane, thereby mediating insulin-stimulated glucose uptake
Phase 3 trials extended to 68 weeks confirmed continued weight loss (28.7% at 68 weeks vs 24.2% at 48 weeks on the 12mg dose)
These agents can concurrently attenuate the lipid-lowering efficacy of statins and compromise bone mineral density, potentially leading to metabolic disorders and secondary hyperparathyroidism
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