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Lipedema care is most successful when GLP-1 is only one component of a comprehensive strategy
This observation has raised concerns regarding suboptimal drug exposure, altered pharmacokinetics, and heightened inflammatory burden in obese patients, highlighting the potential need for dose optimization or alternative treatment strategies in this population ( The impact of BMI on treatment response is well illustrated by the AQUILA study, which examined real-world outcomes in PsA patients treated with ( However, the relationship between BMI and response to biologic therapies is not uniformly consistent across studies
This correlation does not imply causation by semaglutide, but it underscores the importance of monitoring thyroid function in patients receiving the medication, especially if they present risk factors for thyroid disease
Injection site reactions are also relatively common and may include redness, itching, swelling, or mild pain at the injection site
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