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In agreement with histological staining, mRNA levels of several markers, including Mmp13 , Timp1 , Tgf and Col3a1 were significantly upregulated in both male and female PBS-treated SKO mice when compared to the PBS-treated WT group ( Figures 3E, F )
Despite interfering with insulin response in human muscle and adipose tissue, the synthesis of glucagon-like peptide-1 (GLP-1), a well-known glucose-lowering hormone, can also be influenced by pancreatic cancer cells
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