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The decreased body weight in GLP-1RA/tesaglitazar-treated mice was associated with a decrease in body fat mass, with only a slight but significant decrease in lean tissue mass (Fig
Liu, Tamar Yalda, Pin-Jung Chen, Jun Gong, Cristina R
[19] Pre-existing significant gastrointestinal motility disorders (such as severe gastroparesis) warrant caution with GLP-1 medications
However, it additionally raises the possibility of a direct brain effect of GLP-1 receptor agonists that could target mental disorders common in obesity and T2D
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