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Upon recognition of MSU crystals, the NLRP3 inflammasome is activated, leading to the cleavage of pro-inflammatory cytokines, specifically interleukin-1 (IL-1) and interleukin-18 (IL-18)
Many treatments target symptoms, not root causes
Warnings Acetyl-L-carnitine was reported to increase chemotherapy-induced peripheral neuropathy in breast-cancer patients undergoing taxane-based chemotherapy, however the underlying mechanism was not clear (Hershman 2018)
CJC-1295 is a GHRH analog acting through the GHRH receptor
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