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This can increase sodium and water excretion and may slightly reduce circulating blood volume

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Synthetic VSMCs secrete matrix to form plaque fibrous caps, but sustained Chemerin/ChemerinR1 activation thins caps, increasing plaque instability

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Autophagy regulates VDAC3 ubiquitination by FBXW7 to promote erastin-induced ferroptosis in acute lymphoblastic leukemia

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Their main side-effects are nausea and vomiting, and this can limit their attractiveness for certain patients

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