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This is mainly because many patients stop the medication early or take lower doses than recommended
Work by Gabery and colleagues (JCI Insight, 2020) using labelled peptide found access to hindbrain and hypothalamic regions including the area postrema and subfornical organ, indicating central nervous system engagement rather than a purely peripheral mechanism
T2DM accounts for more than 90% of all diabetes cases , with approximately 589 million adults aged 20-79 affected worldwide in 2024
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