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Since -oxidation catabolises fatty acids into NADH, FADH 2 , and acetyl-CoA, which enters the TCA cycle, upregulated -oxidation results in the degradation of fatty acids and increased ATP production
Patients should be informed that tirzepatide may reduce the effectiveness of oral contraceptives, particularly during treatment initiation and dose increases
Most patients see meaningful changes within 812 weeks, with continued results over several months
A recent elegant study also found that brain- Gipr knockout mice and humanised ( h ) GIPR knock-in mice with brain- hGIPR deletion showed decreased body weight and improved glucose metabolism [70]
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