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Several mechanisms explain why GLP-1 RAs reduce body weight: Central appetite suppression: GLP-1 receptors in the hypothalamus and brainstem alter hunger signalling and food reward
The peptide's mechanism involves disrupting the FOXO4-p53 interaction specifically in replication-stressed senescent chondrocytes, triggering selective apoptosis while preserving healthy proliferative cells needed for cartilage formation
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Subsequently, western blot analysis was employed to assess the impact of Hspa1a knockdown on ER stress in KK1 cells in this experiment
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