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3.1 Gene regulation method MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression and are implicated in various diseases

The glutathione peroxidase pathway is further regulated by System Xc-, an amino acid antiporter consisting of a disulfide-linked heterodimer of xCT/SLC7A11 and SLC3A2/4F2hc/CD98, and is inhibited by the ferroptosis inducer erastin (4)

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Long-term studies are also needed to assess whether GLP-1RAs can prevent progression from PsO to PsA, improve musculoskeletal outcomes, and reduce systemic comorbidities such as cardiovascular disease