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Sensitivity Analyses A probabilistic sensitivity analysis (PSA) was performed using a second-order Monte Carlo approach, with sampling around the base case clinical inputs based on the standard errors of the proportions of patients achieving targets collected in the PIONEER 2, 3, and 4 trials (Table 1)
Avoiding high-calorie and sugary foods can also be beneficial
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They all needed more than 2.1 g/day, with some subjects requiring up to 3.0 g/day to remain in positive nitrogen balance
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