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Additionally, patients on dual therapy would face doubled medication costs, doubled adherence burden, and no clinical evidence of superior outcomesmaking the risk-benefit calculation clearly unfavorable compared to optimizing a single agent
It can prevent expensive mistakes
Suppresses glucagon secretion from pancreatic alpha-cells under hyperglycemic conditions in cell-based assays
However, because bradycardia is usually related to problems with cardiac conduction, the only method currently available to consistently increase heart rate is the use of a pacemaker
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