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Drugs such as semaglutide, liraglutide, exenatide, and dulaglutide have been shown to significantly reduce body weight, BMI, and BMI z-score in children and adolescents, with semaglutide demonstrating the greatest efficacy among the class
Although GLP-1 receptor agonists do not completely eliminate dopamine function, these medications appeared to reduce substance-induced dopamine activity without consistently suppressing baseline dopamine signaling
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