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Core analytical requirements include: Primary structure confirmation using LC-MS/MS to verify intact mass, sequence integrity and detect modifications Impurity profiling (e.g., sequence variants, degradation products) using high-resolution techniques such as UHPLC-HRMS Aggregation and molecular weight analysis using orthogonal methods like SEC-MALS and sedimentation velocity analytical ultracentrifugation (SV-AUC)

In a recent randomized, double-blind, placebo-controlled clinical trial, Quer supplementation (500 mg/day, P.O for 8 weeks) evidently improved serum total antioxidant capacity (TAC) in postmyocardial infarction patients compared to the placebo group [126]

Tarjus et al., 2017), more research is required to explain the reported deleterious role of endothelial ENaC in vascular stiffening (Zhang et al., 2022