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G6PD reduces a molecule of NADP to NADPH + H + , which then reduces glutathione disulfide into GSH (reduced glutathione)
Chronic hyperglycemia leads to glucose auto-oxidation and excessive ROS production, overwhelming the antioxidant defense system and disrupting redox homeostasis [107,108,109,110,111]
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Additionally, a 10-week study in overweight or obese post-menopausal women with prediabetes found that 250 mg NMN per day partially increased muscle insulin signaling and sensitivity, but no change in mitochondrial oxidative capacity was found 324
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