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Biochim Biophys Acta (2017) 1863(5):103745
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A as well as its lipid carrier ApoE (encoded by the homonymous susceptibility gene) are vasculopathic, proinflammatory, impair A degradation by microglial cells and astrocytes, impede efficient clearance and induce a degeneration of endothelial cells which is independent of other conditions (Kurz et al., 2021)
Modifications in neurotransmitter levels by modulatory pathways such as the kynurenine pathway, and also changes in accessibility and effects of SCFAs in the brain, may have an impact on BDNF activities such as neural survival and CNS development (70)
