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The essential link between the mitochondrial carnitine transport and FAO is demonstrated by the life-threatening inherited carnitine/acylcarnitine translocase deficiency (OMIM 613698) that, in contrast to the PCD caused by OCTN2 defects, cannot be compensated by the administration of carnitine (Indiveri et al., 2011)
It shows quick results in 1-2 sessions, though the cost per session is higher (approx
Clinical trials have demonstrated substantial reductions in hemoglobin A1c levels (up to 2.4% reduction at the 15 mg dose) and significant weight loss (average of 15% of body weight at 10 mg and 20.9% at 15 mg in the SURMOUNT-1 obesity trial)
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