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The frequency in Australia has been estimated to be between 1:37,000 and 1:100,000
10.1002/jcp.1041190207 97 SakaiK.AokiS.MatsumotoK
The excess floods the pituitary with GHRH signal, leading to receptor desensitization within days rather than months
Yet the FDA has reported hundreds of adverse event reports allegedly linked to compounded versions of these drugs, which do not undergo the same rigorous manufacturing inspections and clinical testing as approved brands
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