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If there is any uncertainty about whether the medication was frozen, exposed to excessive heat (above 86F), or stored beyond the recommended timeframe, the safest approach is disposal and replacement
Since then, the Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity (SELECT) cardiovascular outcomes trial has shown that semaglutide 2.4 mg once weekly was associated with a significant 20% relative risk reduction in major cardiovascular adverse events compared with placebo [38]
Tablet formulations of oral semaglutide commonly include absorption-support technology because semaglutide is a peptide medicine and would otherwise be poorly absorbed in the stomach
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