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J Neuroimmunol 207(1):111116

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Why Weight Gain Reflects Metabolic Dysfunction Persistent hunger, cravings, fatigue, and weight resistance often indicate underlying dysfunction, including: Impaired insulin sensitivity Leptin resistance Chronic low-grade inflammation Gut microbiome imbalance Nutrient deficiencies affecting cellular energy production When these factors are present, the body adapts by conserving energy and increasing appetiteregardless of calorie intake (22)

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