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These stresses rapidly elevate the cellular levels of Ca 2+ and increased cytosolic Ca 2+ stimulates calmodulin-dependent glutamate decarboxylase activity and GABA synthesis (Bhattacharya et al

E., & Smith, A

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Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (surpass-3): A randomised, open-label, parallel-group, phase 3 trial