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Weeks 1-4 Starting dose to assess tolerance Weeks 5-8 First dose increase Weeks 9-12 Therapeutic effects begin Weeks 13-16 Approaching target dose Week 17+ Full maintenance dose Side Effects & Safety Most gastrointestinal side effects are mild, temporary, and occur during the dose escalation period
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During this process, excess iron could induce the excessive accumulation of ROS, which leads to oxidative stress and damages mitochondrial function in preimplantation mouse embryos
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