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Our findings raise the possibility of using PEPITEM derived peptides for the treatment of psoriasis." "This study also raises the interesting possibility that PEPITEM derived peptides could be used in combination with other psoriasis therapies, allowing lower dosing for longer durations, for example, a 'steroid sparing' approach, to reduce the side effects associated with prolonged use of such agents." Further investigation showed both the whole PEPITEM molecule and the tripeptide sequences are powerful regulators for the synthesis of signalling molecules that promote inflammation, leading to the recruitment of immune cells and proliferation of other cell types in skin tissue involved in disease, with some tripeptide sequences showing an order of magnitude increase in efficacy compared to the parent PEPITEM sequence

The exact cause of IBS is not fully understood, but it is believed to involve a combination of gut motility issues, inflammation, and sensitivity to various triggers

doi:10.1016/bs.afnr.2017.11.005

Intermediate users commonly use 300-400 mcg daily, while advanced protocols may utilize 500 mcg daily or divided doses of 250 mcg twice per day