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Curcumin showed dose-dependent antiproliferative activity, cytotoxicity, and apoptosis, increased ROS, reduced Bax/Bcl-2 ratio, and expression of CDK4 and cyclin D1 in breast cancer cells [83]

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More recently, miR-141-3p, downregulated by lncRNA HIF1A-AS2, has been shown to promote CRC metabolic reprogramming and proliferation through FOXC1 activation, highlighting additional post-transcriptional networks under hypoxic stress [114]