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PMCID: PMC4290711
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The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study
Right, percent of cell number from Slc33a1 -knockout KPK cells expressing a vector control or SLC33A1 cDNA treated with DMSO or thapsigargin (Tg) for 4 days under indicated concentrations
Motilin enhances smooth muscle contractility in the stomach and small intestine, promotes gastric acid and pepsin secretion, influences gallbladder emptying, and increases lower esophageal sphincter tone
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