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Clinical trials show probiotics produce modest weight loss of 0.5-2 kg, while FDA-approved medications like semaglutide and tirzepatide demonstrate 15-21% body weight reduction with robust clinical evidence

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Water retention and stress hormones might make weight go up

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Dulaglutide Dulaglutide, developed by Eli Lilly, achieves its long-acting effect by being linked to a human IgG4-Fc heavy chain, which helps resist degradation by DPP-4

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Patients whove had a kidney transplant require a bespoke assessment and written clearance from their transplant nephrologist before starting treatment

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