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Some users find they respond well to lower doses and never need to reach the peak phase amounts

Some researchers have speculated that patients in certain clinical trials, particularly the CASTA stroke trial, may have received inadequate doses, potentially explaining the mixed results in the overall population analysis

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Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]