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The first case involves a 54-year-old man who, about one month after starting semaglutide, experienced a marked decline in energy, motivation, fatigue, difficulty concentrating, and mood disturbances
Low C Rating: Promotes long-term durability but limits power output
308 , F878F887 (2015)
Study limitations include presence of statistical heterogeneity in the meta-analyses for change in HbA 1c and body weight, assessment of risk of bias solely for the primary outcome, and generalisation of findings mainly to individuals who are overweight or obese and already on metformin-based background therapy
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