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Semaglutide and liraglutide effects on central nervous system regulation GLP-1 and GLP-1RA are involved in the activation of various central nervous system (CNS) processes, including satiety, thermogenesis, blood pressure, neurogenesis, and inflammation reduction (15)

Clinical trial data shows retatrutide has somewhat higher rates of GI side effects (nausea, diarrhea, vomiting) compared to tirzepatide, likely due to the additional glucagon receptor activation

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Oral semaglutide comes as a pill you swallow once each day