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This effect of GLP-1(2836) was independent of the known GLP-1R and was mediated by a mechanism involving mitochondrial MTP and intracellular sAC in caSMCs and caECs but not CMs

Pharmacokinetics and exposure All seven completers having undergone PET assessments at the end of treatment were exposed to SAR425899 plasma levels comparable to other clinical studies having applied similar dose levels